5 ESSENTIAL ELEMENTS FOR POS88

, 2006; Sawaya and Kraut, 1997; Figure 1—figure health supplement one), we expected the mutational landscape of DHFR to be constrained by the requirement to undertake these different conformations. What's more, prior perform had proposed DHFR is impacted by cellular constraints for instance protein top quality Handle (Bershtein et al., 2013) as